Protective Immune Responses to the 42-Kilodalton (kDa) Region of Plasmodium yoelii Merozoite Surface Protein 1 Are Induced by the C-Terminal 19-kDa Region but Not by the Adjacent 33-kDa Region

Parasite-Specific Antibodies Protein-1-Specific Antibodies but Not Whole Region of Merozoite Surface Maternally Derived 19-kDa C-Terminal Antibody Responses in Neonatal Pups by Merozoite Surface Protein-1-Specific Inhibition of 19-kDa C-Terminal Region of

ficolin-a enhances inhibition of the c-terminal 19 kda region of merozoite surface protein-1 of plasmodium berghei using test in vivo.

background : malaria remains a serious public health problem with significant morbidity and mortal-ity. this study was conducted to identify whether ficolin-a could play an active role of against mala-ria infection. methods : the function of ficolin-a was analyzed in mouse model. the open reading frame of fico-lin-a was cloned from the liver of new born c57bl/6 mice by rt-pcr and then inserted ...

Ficolin-A Enhances Inhibition of the C-Terminal 19 kDa Region of Merozoite Surface Protein-1 of Plasmodium berghei Using Test In Vivo

BACKGROUND Malaria remains a serious public health problem with significant morbidity and mortality. This study was conducted to identify whether ficolin-A could play an active role of against malaria infection. METHODS The function of ficolin-A was analyzed in mouse model. The open reading frame of ficolin-A was cloned from the liver of new born C57BL/6 mice by RT-PCR and then inserted into ...

Distribution of Antibodies Specific to the 19-kDa and 33-kDa Fragments of Plasmodium vivax Merozoite Surface Protein 1 in Two Pathogenic Strains Infecting Korean Vivax Malaria Patients

OBJECTIVES Plasmodium vivax merozoite surface protein 1 (PvMSP1) is the most intensively studied malaria vaccine candidate. Although high antibody response-inducing two C-terminal fragments of PvMSP1 (PvMSP1-19 and PvMSP1-42) are currently being developed as candidate malaria vaccine antigens, their high genetic diversity in various isolates is a major hurdle. The sequence polymorphism of PvMSP...

Naturally acquired antibody responses to the C-terminal region of merozoite surface protein 1 of Plasmodium vivax in Korea.

We expressed a protein in Saccharomyces cerevisiae in order to evaluate the humoral immune responses to the C-terminal region of the merozoite surface protein 1 of Plasmodium vivax. This protein (Pv200(18)) had a molecular mass of 18 kDa and was reactive with the sera of individuals with patent vivax malaria on immunoblotting analysis. The levels of immunoglobulin M (IgM) and IgG antibodies aga...